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10,14 A further action of DMF is to modulate transcription factors that are sensitive to oxidative stress such as hypoxia-inducible-1a and STAT3/STAT1

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Strong oxidants such as hydrogen peroxide (H 2 O 2 ) instead readily modify protein thiols beyond reversible redox states, to form sulfinic (-SO 2 H) and sulfonic acids (-SO 3 H), thus preventing conversion into the disulfide-linked pathological species dsNNTTR

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